The antibody has a proven strong Biotin-Streptavidin/HRP staining at a 1/8000-1/10,000 dilution in rat amygdala, cortex, and suprachiasmatic nucleus. The specificity of the antiserum was examined by soluble pre-adsorption with the peptides in question at a final concentration of 10-5 M. VIP immunolabeling was completely abolished by pre-adsorption with VIP. Pre-adsorption with the following peptides resulted in no reduction of immunostaining: Secretin, gastric inhibitory polypeptide, somatostatin, glucagon, insulin, ACTH, gastrin 34, FMRF-amide, rat GHRF, human GHRF, peptide histidine isoleucine 27, rat pancreatic polypeptide, motilin, peptide YY, substance P, neuropeptide Y, and CGRP. The histochemical antibody for VIP is generated in a rabbit against porcine VIP conjugated to bovine thyroglobulin with carbodiimide. The antibody is provided as 100 µL of lyophilized whole serum, and 0.09% sodium azide.

Photo Description: IHC image of rat cortex (above) and low magnification image of rat striatum and amygdala staining for VIP (below). The tissue was fixed with 4% formaldehyde in phosphate buffer, before being removed and prepared for vibratome sectioning. Floating sections were incubated at RT in 10% goat serum in PBS, before standard IHC procedure. Primary antibody was incubated at 1:5000 for 48 hours, goat anti-rabbit secondary was subsequently added for 1 hour after washing with PBS. Light microscopy staining was achieved with standard biotin-streptavidin/HRP procedure and DAB chromogen.

Host:Rabbit

Quantity / Volume: 100 µL

State: Lyophilized Whole Serum

Reacts With: Avian (Bird), Bat, Bubalus Bubalis (Buffalo), Bullfrog, Canine, Cat, Chick, Chicken, Dog, Dove, Fish, Fowl, Fox, Frog, Gilt (Pig), Goldfish, Guinea Pig, Hamster, Hedgehog, Hen, Human, Lizard, Mink, Mole, Mollusk, Monkey, Mouse, Mudpuppy (Necturus Maculosus), Ovine, Pig, Pigeon, Platypus, Possum, Rabbit, Raccoon, Ram, Rat, Scorpaena Porcus (Fish), Sea Lamprey, Sheep, Shrew, Snake, Sparrow, Sparus Aurata (Fish), Squirrel, Starfish, Sting Ray, Suncus Murinus, Tadpole, Turkey, Turtle, Worm (Spionidae), Zebra Finch, Zebrafish

Availability: In Stock

Preabsorption Control: Available at Sigma Aldrich, Catalog # V6130

Alternate Names:  Vasoactive intestinal polypeptide; VIP peptides, anti-VIP

Gene Symbol:  VIPRRID:  AB_572270Database Links:  Entrez Gene: 102254866     Bat  Entrez Gene: 100217965     Bird  Entrez Gene: 102407426     Buffalo  Entrez Gene: 101101640     Cat  Entrez Gene: 396323          Chicken  Entrez Gene: 484038          Dog  Entrez Gene: 102095706     Dove  Entrez Gene: 102898768     Fox  Entrez Gene: 373781          Frog  Entrez Gene: 100735454     Guinea Pig  Entrez Gene: 100773469     Hamster  Entrez Gene: 7432              Human  Entrez Gene: 101713745     Mole  Entrez Gene: 703566          Monkey  Entrez Gene: 22353            Mouse  Entrez Gene: 100500718     Pig  Entrez Gene: 100352512     Rabbit  Entrez Gene: 100145884     Ram  Entrez Gene: 117064          Rat  Entrez Gene: 102066375     Sparrow  Entrez Gene: 101977899     Squirrel  Entrez Gene: 102457597     Turtle  Entrez Gene: 795653           Zebrafish

阿尔茨海默氏症协会称，阿尔茨海默氏症的研究抗体在帮助科学家找到解决这种疾病和其他痴呆症的方法方面发挥着重要作用，这些疾病和痴呆症影响了全世界4700万人和530万美国人，到2050年，这一数字有望增加两倍。随着婴儿潮一代的年龄增长，预计将有2800万人患上这种疾病，其费用将升至美国医疗保险总支出的近四分之一。

自从Aloysius Alzheimer博士于1906年首次描述这种疾病以来，科学家们在了解这种疾病如何影响大脑方面取得了显着进步。十多年后，理解和治疗的突破为阿尔茨海默氏病患者带来了希望。

这些ImmunoStar抗体已在阿尔茨海默氏症的研究中得到证明。用关键字“阿尔茨海默氏病” 搜索我们出版物的数据库，以查找数百种引用这些抗体的出版物。有关神经科学家的意见，请参阅我们的客户推荐书，以赞扬他们从ImmunoStar获得的结果和服务。我们的抗体稳定，高滴度，并且批次间一致，可确保成功染色并获得极佳的价值。